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Workshop

Biotransformation and Disposition of Larger Molecules: Peptides, Nucleotides, Proteins, mAbs, and ADCs


Speakers:
Organizers: Dian Su (Genentech)
Date: 9/13/2019
Time: 8:45-17:00
Registration fee (USD): Regular: $195; Academic: $125; For unemployed or students: $30; For major-sponsor rep (incl lunch): $0; For vendor-show rep: $35;
Location: SF Bay Area: Foster City Crowne Plaza
Major Sponsor:
Vendor show vendors registered to date: (1)MicroConstants
Registration: http://www.PBSS.org
Registration deadline:9/11/2019  (it will close sooner if the seating cap is reached)

About the Topic

​Biotransformation of small molecules is intensively investigated during drug discovery and development stages. In contrast, biotransformation of larger molecules such as antibodies, proteins, antibody-drug conjugates, peptides and nucleotides has been less emphasized. In the last decade, there have been increasing interests and expertise in understanding of larger molecule biotransformation and disposition. This workshop will cover this topic for diverse therapeutics and provide an opportunity for the community to discuss the technical aspect, role and impact of biotransformation for development of larger molecule therapeutics.

Key topics:

  • Introduction to Disposition and Biotransformations of Larger Molecules 
  • Biotransformation and Trafficking of Peptide Therapeutics
  • Biotransforamtionand biodistribution of Oligonucleotide Therapeutics 
  • Biotransformation of Antibody Therapeutics
  • Biotransformation of Next-generation ADCs
  • Tissue Disposition of Protein and Antibody Therapeutics


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2019-05-06, CMC Development for Biologics: Purification, Formulation, Analytical Characterization, Production Systems, Regulatory and Product Development
2019-06-11, Advances in Immuno-Oncology (A Joint Symposium by PBSS and BioScience Forum)
2019-07-26, Advances in Enzyme Engineering (tentative)
2019-10-03, Small-Molecule Bioanalytical Method Validation & Regulated Bioanalysis: Fundamentals, the New FDA Guidance and Regulatory Trends
2019-10-18, Physiologically Based Pharmacokinetic (PBPK) Modeling: Fundamentals, Regulatory Guidance & Applications
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