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Symposium

[Free Online Symposium] The Drug Discovery and Development Journey of Polivy™ (Polatuzumab Vedotin): An Antibody-Drug Conjugate for the Treatment of Diffuse Large B-cell Lymphoma


Speakers: Andy Polson (Discovery Lead), Dale Miles (Clinical Pharmacology Lead), Donglu Zhang (DMPK with regulatory responses): ALL Principal Scientists from Genentech
Organizers: Cyrus Khojasteh, PhD
Date: 2020-11-13
Time: 11:00-13:00 Pacific Time
Registration fee: (USD):
Location: Online via Zoom
Major Sponsor:
Vendor show vendors registered to date:
Registration: http://www.PBSS.org
Registration deadline:2020-11-11  (it will close sooner if the seating cap is reached)

About the Topic

Polatuzumab vedotin (POLIVY) is an antibody-drug conjugate (ADC) that contains a humanized immunoglobulin-G1 (IgG1) anti-human CD79b monoclonal antibody and a potent anti‑mitotic agent, monomethyl auristatin E (MMAE), linked through a protease‑cleavable linker, maleimidocaproyl‑valine‑citrulline‑p‑aminobenzyloxycarbonyl (mc‑vc‑PAB). Polatuzumab vedotin has been recently approved in US, Canada, and European Countries to treat B-cell lymphomas. This symposium covers an overview of POLIVY discovery and development which will include its early discovery and clinical readouts, novel clinic pharmacology strategies, and unique regulatory response strategies. The audience will learn about a successful ADC discovery story and embrace the differences between small molecule and ADC drug development.    


2020-10-29, [Free Online Symposium] No More Undruggables: Unconventional Approaches for Drug Discovery and Design - prodrugs, PROTACS, fragment-based design, directed evolution and beyond
2021-07-29, Development of Inhalation Therapeutics (a joint symposium by AAPS-BADGE / PBSS / Genentech)
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