Pharmaceutical & BioScience Society, PBSS

Workshop

Antibody Drug Conjugates: Chemistry, Biology, Pharmacokinetics and Toxicology

Speakers: Jagath Junutula (Cellerant), Andy Polson (Genentech) , Toni Kline (Sutro), Chetana Rao (BMS), Donglu Zhang (Genentech), Keyang Xu, PhD (Genentech), Melissa Schutten (Genentech)
Organizers: Thomas Pillow (Genentech)
Date: 9/12/2018
Time: 8:45-16:00
Registration fee (USD): Regular: $195; For unemployed or students: $30; Academic: $125; For major-sponsor rep (incl lunch): $0; For vendor-show rep: $35;
Location: SF Bay Area: Foster City Crowne Plaza
Major Sponsor: (2)Applied BioMath, LLC; Intertek
Vendor show vendors registered to date: (24)AIT Bioscience; Alturas Analytics; Applied StemCell, Inc.; Averica Discovery Services; BioPharmEquip; Bruker; JOINN Labs; KCAS Bioanalytical & Biomarker Services; MabPlex; Medpace; MicroConstants; Pacific BioLabs; PHARMout Laboratories; Promega; Q2 Solutions; QPS; SCIEX; Sekisui XenoTech, LLC; Selvita Inc.; Sepax Technologies; Shimadzu Scientific Instruments, Inc; Sigma Aldrich; SRI International; WuXi AppTec
Registration: http://www.PBSS.org
Registration deadline:9/11/2018 (it will close sooner if the seating cap is reached)

About the Topic

Linking a small-molecule cytotoxic drug to a monoclonal antibody takes the strengths of both while potentially mitigating the liabilities. The resulting bioconjugates, known as antibody−drug conjugates or ADCs, have been validated clinically, with four approved anti-cancer agents for solid and hematological cancers. This workshop will broadly discuss the strategies for designing, constructing and analyzing ADCs utilizing the latest advances in the field.

This workshop will cover the following specific topics:

Overview of antibody-drug conjugates (ADCs) and clinical progress
Selecting a target for ADCs
The chemistry of linkers and drugs
Site-specific conjugation
Analytical characterization of ADCs
ADC bioanalysis & pharmacokinetics
Preclinical safety/toxicology

Workshop Agenda:

Time	Topic	Presenter
8:45-9:00	Welcome and Introduction	Thomas Pillow
9:00-9:45	1. ADC Discovery & Development	Jagath Junutula
9:45-10:30	2. ADCs for Hematological Malignancies	Andy Polson
10:30-10:45	Break
10:45-11:30	3. Conjugation Modalities for ADC Generation	Chetana Rao
11:30-12:30	Lunch
12:30-1:15	4. ADC Chemistry	Toni Kline
1:15-2:00	5. Small Molecule DMPK for ADCs	Donglu Zhang
2:00-2:15	Break
2:15-3:00	6. Bioanalysis of ADCs	Keyang Xu
3:00-3:45	7. ADC Safety/Toxicity	Melissa Schutten
3:45-4:15	Panel Discussion	All
4:15-4:30	Final Remarks	Thomas Pillow

Other PBSS-San Francisco Bay Events:

2019-04-25, Tox 21 and New Approach Methodology (NAMs): Using Emerging Technologies to Improve Translational Research and Safety Assessment Predictions (jointly by SOT-NorCal & PBSS)

2019-05-06, CMC Development for Biologics: Purification, Formulation, Analytical Characterization, Production Systems, Regulatory and Product Development

2019-06-11, Advances in Immuno-Oncology (A Joint Symposium by PBSS and BioScience Forum)

2019-07-26, Advances in Enzyme Engineering (tentative)

2019-09-13, Biotransformation and Disposition of Larger Molecules: Peptides, Nucleotides, Proteins, mAbs, and ADCs

2019-10-03, Small-Molecule Bioanalytical Method Validation & Regulated Bioanalysis: Fundamentals, the New FDA Guidance and Regulatory Trends

2019-10-18, Physiologically Based Pharmacokinetic (PBPK) Modeling: Fundamentals, Regulatory Guidance & Applications