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Workshop

Biotransformation and Disposition of Larger Molecules: Peptides, Nucleotides, Proteins, mAbs, and ADCs


Speakers: Donglu Zhang (Genentech), Mark Cancilla (Merck), Jing Li (Alnylam Pharmaceuticals), Srikanth Kotapat (Bristol-Myers Squibb), Mei Han (Amgen), Fang Xie (Amgen), Ben Shen (Genentech), Divya Samineni (Genentech), Dian Su (Genentech)
Organizers: Dian Su (Genentech)
Date: 2019-09-13
Time: 8:45-17:00 Pacific Time
Registration fee (USD): Regular: $195; Academic: $125; For unemployed or students: $30; For major-sponsor rep (incl lunch): $0; For vendor-show rep: $35
Location: SF Bay Area: Foster City Crowne Plaza
Major Sponsor: (1)Almac;(Major Sponsorship - afternoon session still open)
Vendor show vendors registered to date: (6)CMIC, Inc.; Intertek; MicroConstants; Promethera Biosciences; Q2 Solutions; Waters Corporation
Registration: http://www.PBSS.org
Registration deadline:2019-09-11  (it will close sooner if the seating cap is reached)

About the Topic

​Biotransformation of small molecules is intensively investigated during drug discovery and development stages. In contrast, biotransformation of larger molecules such as antibodies, proteins, antibody-drug conjugates, peptides and nucleotides has been less emphasized. In the last decade, there have been increasing interests and expertise in understanding of larger molecule biotransformation and disposition. This workshop will cover this topic for diverse therapeutics and provide an opportunity for the community to discuss the technical aspect, role and impact of biotransformation for development of larger molecule therapeutics.

Key topics:

  • Introduction to Disposition and Biotransformations of Larger Molecules 
  • Biotransformation and Trafficking of Peptide Therapeutics
  • Biotransforamtionand biodistribution of Oligonucleotide Therapeutics 
  • Biotransformation of Antibody Therapeutics
  • Biotransformation of Next-generation ADCs
  • Tissue Disposition of Protein and Antibody Therapeutics


2019-10-03, Small-Molecule Bioanalytical Method Validation & Regulated Bioanalysis: Fundamentals, the New FDA Guidance and Regulatory Trends
2019-10-18, Physiologically Based Pharmacokinetic (PBPK) Modeling: Fundamentals, Regulatory Guidance & Applications
2019-11-12, Antibody Drug Discovery and Development: Hit Generation, Engineering, Cell-line Development, IND enabling studies, and Biosimilars
2019-12-10, In Vitro Diagnostics, Companion Diagnostics and Precision Medicine
2020-01-21, Best Practices for Clinical Trial Design
2020-02-11, Drug-Device Combination
2020-02-24, Advanced LC-MS/MS (Day1) & Interpretation of MS/MS CID Spectra (Day2)
2020-05-12, Regulated Large Molecule Bioanalysis: Fundamentals, the New FDA Guidance and Beyond
2020-05-22, No More Undruggables: Unconventional Approaches for Drug Discovery and Design - prodrugs, PROTACS, fragment-based design, directed evolution and beyond
2020-06-23, Advances in Immuno-Oncology (A Joint Symposium by PBSS and BioScience Forum)
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