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Workshop

Antibody Drug Discovery and Development: Hit Generation, Engineering, Cell-line Development, IND enabling studies, and Biosimilars


Speakers: Donald McCarthy, Mohan Srinivasan, Bo Yu, et al
Organizers: Donald McCarthy, Mohan Srinivasan, Bo Yu, Wenfeng Xu
Date: 2019-11-12
Time: 8:45-17:00 Pacific Time
Registration fee (USD): Regular: $195; Academic: $125; For unemployed or students: $30; For vendor-show rep: $35; For major-sponsor rep (incl lunch): $0
Location: SF Bay Area: Foster City Crowne Plaza
Major Sponsor: (2)Abzena; Cytovance Biologics;(Major Sponsorship - lunch session still open)
Vendor show vendors registered to date: (4)BioIVT; JOINN Biologics; MabPlex USA, Inc.; MicroConstants
Registration: http://www.PBSS.org
Registration deadline:2019-11-12  (it will close sooner if the seating cap is reached)

About the Topic

Topics to be covered:

1. Overview of therapeutic mAbs (Doanld McCarthy)
2. Antibody discovery (hit generation & characterization): antibody target category and selection, hybridomas/humanization, phage display, humanized mice or mice with humanized repertoire, single B cell screening technologies, analytical & biophysical methods for antibody characterization (Mohan Srinivasan)
3. Antibody engineering (for activity & stability): unconventional formats (camelids, nanobodies, bispecifics), Fc/glycan engineering, stability assessment, optimization for development (Mohan Srinivasan)
4. in vitro assays and in vivo models for antibody evaluation
5. Cell line development/CMC: Clone selection/cell line development, characterization, purification, formulation, process development, large scale & GMP manufacturing (Bo Yu)
6. IND enabling studies: ADAs/immunogenecity, GLP tox, PD/PK, preparing for and engaging with the FDA
7. Biosimilars: manufacturing, comparability, clinical trial and regulatory approval

 

Organizing Committee: Donald McCarthy, Mohan Srinivasan, Bo Yu, Wenfeng Xu

If you wish to recommend a speaker (including yourself), please contact info@pbss.org with the recommended name and the topic(s).






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┬ęPharmaceutical & BioScience Society, International; Last Modified: 7/22/2019; Visited: 377; Admin Logon
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