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Workshop

MS Courses by Dr. Jack Henion: Advanced LC-MS/MS (Day1) & Interpretation of MS/MS CID Spectra (Day2)


Speakers: Jack Henion, PhD (Emeritus Professor of Cornell University)
Organizers:
Date: 2020-02-24- 02/25/2020
Time: 8:45-17:00 Pacific Time
Registration fee: Per Day: Regular $195; Academic $125; For unemployed or students $35; For vendor-show rep $35; For major-sponsor rep (incl lunch): $0
Location: San Francisco Bay Area: Foster City Crowne Plaza
Major Sponsor:
Vendor show vendors registered to date: (7)ChemoCentryx; MicroConstants; Alturas Analytics; Averica Discovery Services; CP Lab Safety; Cytoscient; KCAS Bioanalytical & Biomarker Services
Registration: http://www.PBSS.org
Registration deadline:2020-02-19  (it will close sooner if the seating cap is reached)

About the Topic

Day 1: Advanced LC/MS Practices

Course Objective:

Learn effective techniques for analyzing complex samples and characterizing organic compounds

Key Topics You'll Learn About

  • Principles and preferred practices for APCI LC/MS
  • Fundamentals and practices for optimal ESI (electrospray ionization)
  • Principles of multiple charging in electrospray mass spectra of biomolecules
  • Strategies for characterizing small molecules contained in biological samples via electrospray LC/MS and LC/MS/MS.
  • Sample preparation optimized for LC/MS and LC/MS/MS analyses
  • Initial strategies for interpreting collision-induced dissociation (CID) mass spectra of small pharmaceutical molecules.

 
Day 2: Interpretation of MS/MS CID Mass Spectra

 This relatively advanced course covers basic concepts for interpreting MS/MS collision-induced dissociation (CID) mass spectra of small molecules such as drugs, metabolites, impurities, degradants, environmental contaminants, etc.  This is a one-day course with six one-hour lectures including extensive problem solving.  The prospective student should have a good understanding of organic chemistry, reaction mechanisms, and the guidelines of physical organic chemistry.  An understanding of EI mass spectral interpretation techniques will also be helpful.

Key Topics You Will Learn

  • Strategies for approaching CID mass spectral interpretation
  • The importance of acquiring high-quality CID mass spectral information for interpretation purposes
  • The nitrogen rule, importance of stable isotope contributions, mass defects, the Retro Diels Alder reaction, accurate mass measurement, high resolution and related topics.
  • Differentiation between simple bond cleavages, alpha cleavages, rearrangements, and ring opening mechanisms
  • Rules for approaching an unknown structure characterization given a good CID mass spectrum
  • Relevance of data from triple quadrupole MS systems, Ion Trap MS, LC-TOF/MS, FTMS, Orbitraps, MSn and other modern analytical information 

 

Day 1, 24 February 2020 PBSS Agenda: Advanced LC/MS Practices

8:45-9:00 . Welcome and Introductions - Shichang Miao

9:00-10:00 . Lecture 3, APCI Introduction and Applications - Jack Henion

10:00-10:15      Break                                      

10:15-11:00 . Lecture 4, Electrospray Introduction - Jack Henion

11:00-12:00 . Lecture 6, Developing and Validating LC/MS Methods - Jack Henion

12:00pm-1:00   Lunch

1:00-2:00 . Lecture 7, Sample Preparation for LC/MS - Jack Henion

2:00-3:00 . Lecture 10, Future Perspectives in Regulated BA -  Jack Henion

3:00-3:30 . Break

3:30-5:00 . Recent Developments - Jack Henion

5:00-5:30 . General Discussion - All

 

Day 2, 25 February 2020 PBSS Agenda: Interpretation of CID Mass Spectra

8:45-9:00 . Welcome and Introductions - Shichang Miao

9:00-10:00 . Lecture 2-Collision-Induced Dissociation - Jack Henion

10:00-10:15 . Break

10:15-11:00 . Lecture 3-Inductive Cleavages  - Jack Henion

11:00-12:00 . Lecture 4-Single Bond Cleavages - Jack Henion

12:00pm-1:00   Lunch

1:00-2:00 . Lecture 5-Ring Opening and Fragmentation - Jack Henion

2:00-3:00 . Lecture 6-Multiple Bond Cleavages - Jack Henion

3:00-3:30 . Break

3:30-5:00 . Lecture 7-Hydrogen Rearrangements - Jack Henion

5:00-5:30 . General Discussion - All


About the Speakers

Jack Henion is Professor Emeritus of Toxicology at Cornell University in the Analytical Toxicology Lab.  He is also a co-founder and CSO of Advion, Inc., located in Ithaca, New York.  Prof. Henion’s work in LC/MS relates to the analysis of real-world samples common to pharmaceutical, environmental, and biochemical problems.  The instructor has published extensively in the areas of conventional capillary GC/MS as well as LC/MS, SFC/MS, IC/MS, and CE/MS using atmospheric pressure ionization (API) technologies with quadrupole, ion trap, FTMS, and time-of-flight mass spectrometers.


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