The Drug Metabolism and Pharmacokinetics (DMPK) group at Genentech is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates. We accomplish this through the application of state of the art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

 The DMPK group is seeking a highly motivated individual to apply drug metabolism in drug design. Primary responsibilities include:

• Hands on work in metabolite identification by LC-MS/MS and determine the biotransformation pathways of small molecules and peptides
• Solid understanding of drug metabolizing enzymes and applications of in silico tools in drug metabolism
• Design, perform and interpret drug metabolism studies with focus on characterizing metabolism pathways and soft-spots in drug discovery
• Integrate metabolism information into guiding chemistry designs 

The level of the position (Associate Scientist or Scientist) will depend on the qualifications of the selected candidate. 

 Qualified candidates will meet the following requirements:

• Ph.D. degree in organic chemistry, medicinal chemistry, pharmaceutical sciences or other relevant discipline with a strong chemistry and experimental metabolism background
• 2+ years of experience in the pharmaceutical industry or post-doc in a similar role is preferred; previous experience working with medicinal chemists to guide drug design is desirable
• Record of accomplishment as evidenced by co-authored publications in scientific journals; first-author publications are required at the Scientist level
• Working knowledge of drug metabolizing enzymes, bioactivation and bioanalytical techniques such as chromatographic separation and LC-MS/MS
• Ability to work independently and as part of a team, along with excellent communication skills
• Proven track record of project leadership is a plus

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