View more job listings or post a job
PTC Therapeutics Scientist I - Translational Omics
Applied BioMath Quantitative Systems Pharmacology Modeler - Project Lead/Group Lead
Sorrento Therapetuics Scientist/Sr. Scientist -- protein/gene characterization, LC-MS
Applied BioMath Senior Scientist - Pharmacometrics
Applied BioMath Senior Scientist - Mathematical Modeler
Evotec Senior Scientist
UC Davis - California Animal Health and Food Safety Laboratory TOXICOLOGY SECTION: LAB RESEARCH SUPERVISOR 2/GROUP LEADER (LAB RSCH SUPV 2)
Catalent Pharma Solutions Scientist - Molecular Biology / Protein Expression
Catalent Pharma Solutions Associate Scientist - Molecular Biology / Protein Expression
Protagonist Therapeutics CLINICAL PHARMACOLOGIST
Post a job

Senior Scientist, DMPK-In Vitro (2021-144)

Mirati Therapeutics



Mirati Therapeutics (NASDAQ: MRTX) is a San Diego-based late-stage biotechnology company relentlessly focused on translating drug discovery and research into new treatments for patients by advancing and delivering novel therapeutics that target the genetic and immunologic drivers of cancer. Mirati is advancing a novel pipeline to treat large patient populations across multiple programs and tumor types, including two programs, adagrasib (MRTX849) and sitravatinib, in registration-enabling studies to treat non-small cell lung cancer (NSCLC).

Adagrasib is an investigational small molecule and selective KRAS G12C inhibitor in clinical development as a monotherapy and in combinations. MRTX1133 is an investigational small molecule, potent and selective KRAS G12D inhibitor in preclinical development.

Sitravatinib is an investigational spectrum-selective inhibitor of receptor tyrosine kinases (RTK) designed to enhance immune responses through the inhibition of immunosuppressive signaling. Sitravatinib is being evaluated in multiple clinical trials to treat patients who are refractory to prior immune checkpoint inhibitor therapy, including a Phase 3 trial of sitravatinib in combination with nivolumab in NSCLC.

The Company has initiated plans to prepare for the commercialization of adagrasib by establishing its commercial and medical affairs team. Mirati's ambition is to continue to recruit and a build a world-class, high-performing team with a shared passion and dedication for transforming the future of cancer treatment.

.We are Mirati

Our mission is to discover, design, and deliver breakthrough therapies to transform the lives of cancer patients and their loved ones. We have built a culture fueled by accountability, urgency, collaboration and open-mindedness, and have established ourselves as an innovator within our industry. As we grow, we are looking to build diverse teams, with skilled individuals that are passionate about their work.

Why join us?

  • The Drug Discovery team at Mirati is responsible for the invention, optimization and characterization of quality small molecules as clinical candidates for Mirati research programs. The Senior Scientist will be responsible for routine hepatocyte stability assays and will perform fit-for-purpose in vitro ADME assays to enable fast progression of discovery programs. The ideal candidate will be self-motivated and comfortable performing hepatocyte based assay and a variety of in vitro ADME assays.

Your Responsibilities:

  • Routinely perform metabolic stability assessments in primary hepatocytes
  • Help design, perform and troubleshoot assays such as CYP450 DDI, protein binding and metabolic stability to support discovery projects and occasionally provide mechanistic studies for leads
  • Provide non-routine in vitro ADME assays to support fast advancement of discovery programs and help evaluate the drug-drug interaction potential of lead compounds
  • Routinely acquire LC/MS data and maintain/troubleshoot lab instruments as needed
  • Prepare reagents and upload assay data to compound database
  • Work effectively within a DMPK group as a key member providing in vitro ADME data
  • Prepare and deliver internal presentations and external publications as driven by the project and corporate strategies.



What is Required:

  • MS with 5+ years, BS with 10+ years of experience in a relevant laboratory environment with analytical chemistry, DMPK and drug discovery background
  • Relevant pharmaceutical or biotech industry experience required
  • Hands-on expertise with hepatocyte-based assays
  • Experience with transporter assays is a plus
  • Extensive experience operating and maintaining Sciex LC-MS systems, liquid handlers and instrumentation to perform day-to-day ADME experiments and assays
  • Proficient in LC/MS software, data processing and presentation of results to project teams
  • Demonstration of outstanding communication skills and flexibility in adapting to a fast-paced environment with multiple projects and shifting priorities

Mirati's policy is to provide equal employment opportunities to all applicants and employees without regards to race, color, religion, creed, gender identity or expression, age, national origin or ancestry, citizenship, disability, sexual orientation, marital status, pregnancy, veteran status, membership in the uniformed services, genetic informations, or any other basis protected by applicable law.

Notice to Third Party Agencies: Please note that Mirati Therapeutics Inc. does not accept unsolicited resumes from recruiters or employment agencies.

Location: San Diego, CA


Post Date: 2/22/2021 12:00:00 AM
┬ęPharmaceutical & BioScience Society, International; Last Modified: 5/10/2021; Admin Logon
Ads (in random order)
Submit a Text Ad
($250 for 2 months)

Alturas Analytics, Inc. Expert GLP & non-GLP LC-MS/MS, GC-MS/MS bioanalytical & PK/TK analysis services of small & large molecules in any matrix. Discovery through phase IV.
Hypha Discovery Synthesis, purification & NMR characterization of drug metabolites at mg-g scale with COAs, including CYP/AOX/FMO metabolites, glucuronides & sulfates
Eurofins Selcia 14C Custom Radiolabelling for pre-clinical studies (ADME, drug metabolism, QWBA) and GMP 14C-API for hAME, clinical mass balance /micro-dosing.
Submit a Text Ad