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Senior Scientist In Vitro ADME, R&D - San Diego, CA



Janssen R&D, a member of Johnson & Johnsons Family of Companies, is recruiting for an In Vitro ADME (Absorption, Distribution, Metabolism, Excretion) Senior Scientist with expertise in executing in vitro ADME studies, for the Department of Drug Metabolism and Pharmacokinetics (DMPK) department, located in San Diego, CA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found!

Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Driven by our commitment to patients, we develop sustainable, integrated healthcare solutions by working side-by-side with healthcare stakeholders, based on partnerships of trust and transparency. Please visit for more information.

We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion! Proud to be an equal opportunity employer.

The Department of Drug Metabolism & Pharmacokinetics is a critical part of the Discovery Sciences organization in Janssen R&D and is committed to the delivery of high-quality clinical candidates in all Therapeutic Area (TA) discovery teams. We are currently seeking an outstanding individual to join our mechanistic in vitro ADME team as a Senior Scientist to support the Discovery and Early Development portfolio. This individual will work closely with other DMPK team members to provide timely and seamless delivery of quality data and with other functions (Chemistry, Biology) to guide drug candidate selection. This position will be based in San Diego, CA, and may require <10% travel.




The qualifications include a B.S. with 12+ years, M.S. with 10+ years or a PhD with 3+ years of relevant industry experience utilizing ADME-related in vitro models. Preferably, the M.S. or PhD would be in Pharmaceutical Sciences or a related field.

Experience And Skills:


  • The candidate should have a strong technical understanding of DMPK principles and in vitro ADME assay design and translation to in vivo findings.
  • Experience designing and executing in vitro assays using cells, subcellular fractions and other biological matrices (e.g. plasma, blood) to understand the mechanism of in vivo findings.
  • Hands-on experience with LC-MS sample analysis.
  • Proficiency in applying software (Excel, GraphPad Prism, Analyst) for data analysis and graphics.
  • Excellent interpersonal, organizational, oral/written communication and teamwork skills.
  • Experience in supervising/mentoring junior lab personnel


  • Hands-on experience with LC-MS (preferably Sciex platform) instrumentation and method development.
  • Experience with assay automation and robotic systems
  • Experience with long-term hepatocyte co-culture systems such as HuREL or HepatoPac
  • Transporter expertise to assist in assay development and interpretation of transporter assay results       

Location: San Diego, CA

Contact: Laurie Volak (

Post Date: 7/27/2021 10:16:13 AM
┬ęPharmaceutical & BioScience Society, International; Last Modified: 10/18/2021; Admin Logon
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