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Principal Scientist, DMPK (small molecule therapeutics)

Denali Therapeutics


Denali Therapeutics is seeking to hire a Principal Scientist, DMPK with expertise in small molecule drug discovery and early development.  The successful candidate will be expected to lead the DMPK strategy on projects, guiding and implementing strategies throughout the life cycle of small molecule therapeutics. The incumbent will be a key team member for identifying and advancing lead drug candidates in collaboration with colleagues in Medicinal Chemistry, Safety Assessment, Biology, Development Sciences, and Clinical Development.


  • Be a key contributor to DMPK strategy from drug discovery to drug development and filing by acting on interdisciplinary project teams to identify and address ADME-centered matters for small molecule therapies
  • Guide project teams to characterize, select, and advance small molecules with ADME properties that are fit to the therapeutic profile; accomplishing this through designing and integrating data from in vitro and preclinical pharmacokinetic/toxicokinetic studies, and translating to predictions of human PK, PD, and safety
  • Act as a key member of Pharmacology teams to develop and execute strategies for nonclinical and clinical ADME characterization of candidate molecules to support their advancement in clinic studies
  • Serve as a subject matter expert to write Nonclinical Pharmacology sections of regulatory (IND/CTA) filings, IB updates, and responses to regulatory queries
  • Identify and employ new technologies and strategies that address current and future ADME challenges
  • Mentor DMPK scientists

  • MS or PhD in Drug Metabolism, Pharmacokinetics, Chemistry, or related scientific discipline with a minimum 8-10 years of biotech/pharmaceutical drug discovery and development experience
  • Excellent critical thinking and scientific skills with proven scientific expertise in small molecule metabolism and pharmacokinetics
  • Demonstrated ability to work effectively and collaboratively with scientists on cross-functional projects teams
  • Excellent oral presentation and written communication skills

Location: South San Francisco

Contact: Apply at:

Post Date: 9/10/2021 8:19:19 AM
┬ęPharmaceutical & BioScience Society, International; Last Modified: 10/18/2021; Admin Logon
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